misfortune vs tough luck

misfortune and tough luck both are nouns.

Word	Noun	Adjective	Verb	Adverb
misfortune	Yes	No	No	No
tough luck	Yes	No	No	No

As nouns, misfortune and tough luck are synonyms defined as:

misfortune and tough luck: an unfortunate state resulting from unfavorable outcomes

Other synonyms of misfortune include bad luck, ill luck.

misfortune (noun)	tough luck (noun)
unnecessary and unforeseen trouble resulting from an unfortunate event	an unfortunate state resulting from unfavorable outcomes
an unfortunate state resulting from unfavorable outcomes