misfortune vs weakness

misfortune and weakness both are nouns.

Word	Noun	Adjective	Verb	Adverb
misfortune	Yes	No	No	No
weakness	Yes	No	No	No

As nouns, weakness is a hyponym of misfortune; that is, weakness is a word with a more specific, narrower meaning than misfortune:

Other hyponyms of misfortune include adversity, hard knocks, hardship, gutter, sewer, toilet, hard cheese.

misfortune (noun)	weakness (noun)
unnecessary and unforeseen trouble resulting from an unfortunate event	the property of lacking physical or mental strength; liability to failure under pressure or stress or strain
an unfortunate state resulting from unfavorable outcomes	powerlessness revealed by an inability to act
	a penchant for something even though it might not be good for you
	a flaw or weak point
	the condition of being financially weak