tough luck vs misfortune

tough luck and misfortune both are nouns.

Word	Noun	Adjective	Verb	Adverb
tough luck	Yes	No	No	No
misfortune	Yes	No	No	No

As nouns, tough luck and misfortune are synonyms defined as:

tough luck and misfortune: an unfortunate state resulting from unfavorable outcomes

Other synonyms of tough luck include bad luck, ill luck.

tough luck (noun)	misfortune (noun)
an unfortunate state resulting from unfavorable outcomes	unnecessary and unforeseen trouble resulting from an unfortunate event
	an unfortunate state resulting from unfavorable outcomes