tragedy vs misfortune

tragedy and misfortune both are nouns.

Word	Noun	Adjective	Verb	Adverb
tragedy	Yes	No	No	No
misfortune	Yes	No	No	No

As nouns, misfortune is a hypernym of tragedy; that is, misfortune is a word with a broader meaning than tragedy:

tragedy: an event resulting in great loss and misfortune
misfortune: unnecessary and unforeseen trouble resulting from an unfortunate event

Other hypernyms of tragedy include bad luck.

tragedy (noun)	misfortune (noun)
drama in which the protagonist is overcome by some superior force or circumstance; excites terror or pity	unnecessary and unforeseen trouble resulting from an unfortunate event
an event resulting in great loss and misfortune	an unfortunate state resulting from unfavorable outcomes