fate vs misfortune

fate and misfortune both are nouns.

Word	Noun	Adjective	Verb	Adverb
fate	Yes	No	Yes	No
misfortune	Yes	No	No	No

As nouns, misfortune is a hyponym of fate; that is, misfortune is a word with a more specific, narrower meaning than fate:

fate: your overall circumstances or condition in life (including everything that happens to you)
misfortune: an unfortunate state resulting from unfavorable outcomes

Other hyponyms of fate include good fortune, good luck, luckiness, providence, bad luck, ill luck, tough luck, failure.

fate (noun)	misfortune (noun)
an event (or a course of events) that will inevitably happen in the future	unnecessary and unforeseen trouble resulting from an unfortunate event
the ultimate agency regarded as predetermining the course of events	an unfortunate state resulting from unfavorable outcomes
your overall circumstances or condition in life (including everything that happens to you)

fate (verb)	misfortune (verb)
decree or designate beforehand